Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow.

In addition, apart from a borderline significant increase ( p = 0.048) in mean hepatic blood flow, no significant anti-VEGF-induced differences were observed ( p >0.05) in two additional physiological parameters, interstitial fluid volume and the organ blood flow rate, measured using indium-111-pentetate and rubidium-86 chloride, respectively.

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In addition, with the exception of a marginally significant increase in hepatic blood flow, no anti-VEGF-induced differences were detected in interstitial fluid volume and organ blood flow rates.

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