Barely Significant
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Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.

Biochem Biophys Res Commun · 2011 · PMC3061319 · PMID 21320471

Europe PMCDOI
1
hedged sentence
0.0550
closest p · 1.1× alpha
0.0550
boldest claim

The sentences

almost reached significancep = 0.055so close (0.05 < p ≤ 0.1)
No correlation was also found between Nrf2 and DJ-1 ( r = −0.45, p = 0.12) but the correlation with Keap1 almost reached significance ( r = −0.54, p = 0.055), which has been previously observed in cancer cells [22] . 3.6 HDAC2 is associated with Nrf2 and HDAC reduction causes acetylation of Nrf2 In order to measure acetylation levels of Nrf2, high amount of the protein were obtained by treating BEAS2B cells with MG132, a proteasome inhibitor, preventing degradation of Nrf2.

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