Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus.

Despite a trend for a global treatment effect, IGF levels were not significantly different between the three groups whatever the photoperiod ( p = 0.078). Highly significant differences in testis size (Fig. 7a ) and testosterone levels (Fig. 7b ) occurred between each photoperiod ( p < 0.001) but treatment did not affect these parameters ( p = 0.726 and p = 0.203, respectively).

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Water turnover did not differ according to photoperiod or treatment but the cross effect was almost significant ( p = 0.055).

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However, a crossed effect close to significance was observed, with a decrease in FFM in LD compared with SD for CTL and CR animals, whereas inversely RSV-treated lemurs increased their FFM in the LD season.

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