Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus.

There was a highly significant effect of treatment (Kruskal-Wallis test, χ 2 3 = 11.57, P = 0.009 across all 4 treatment groups), that was dose-related ( r s = -0.773, n = 19, p < 0.001).

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However, analysis by 2-way rmGLM with PLS treatment and cimetidine treatment, as factors and time as the within subjects factor, indicated that the divergence of FEC between treatment groups was of borderline significance only [PLS treatment *time, on log 10 (EPG+25) transformed data, within subjects test, F 3.5, 56.4 = 2.589, p = 0.053].

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However, confining the analysis to the two infected groups to ascertain whether repeated administration was more effective than a single dose treatment gave only a borderline significance (treatment*time interaction, F 2.4, 19.3 = 3.21, p = 0.053) and there was no significant difference between the single dose treatment and the control group (post-hoc test, treatment*time interaction, F 1,8 , = 1.26, p = 0.3).

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