In multivariate analysis, the ERCC1 19442C > A genotype was an independent predictor for TTP with borderline significance after adjustment for ECOG performance status, sex, and number of organs with metastases (adjusted HR for patients carrying C/C compared with patients carrying A/A genotype as a reference, was 2.365 (95% CI, 0.909–6.155; P =0.078) ( Table 4 ).
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CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients.
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