As there may be significant variation between local estrogen synthesis in addition to uptake of estrogens from the circulation in some tumours, direct measurement of intratumour estrogens is required to assess the potency of AI estrogen suppression in malignant target tissues ( Lønning and Geisler, 2008 ).
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Differences between the non-steroidal aromatase inhibitors anastrozole and letrozole--of clinical importance?
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