Thus, aberrant modulation of BK Ca channels by AMPK may be significant in a variety of disorders where BK Ca channel dysfunction has been implicated, such as hypertension ( 30 , 34 ), incontinence ( 35 ), ataxia ( 36 ), and epilepsy ( 20 ).
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Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase.
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