Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.

J Hematol Oncol · 2011 · PMC3069946 · PMID 21418662

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an overall trendno p-value reported

Over time, symptom-free intervals shorten, and finally symptoms become chronic with intensity which fluctuates but with an overall trend toward steadily increasing intensity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.