Discretization provides a conceptually simple tool to build expression networks.

PLoS One · 2011 · PMC3078920 · PMID 21533165

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highly significantno p-value reported

No attempt is made to distinguish possible causal links as the search for biomarkers would be crippled by losing highly significant co-expression relationships.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.