highly significantP = 5.4 × 10 −5
The highly significant association is replicated ( P = 5.4 × 10 −5 ) with an estimated OR of 1.9 (95% CI, 1.2-2.6).
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Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.
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0.0001
0.0001
The sentences
The robustness of this association is demonstrated by replication within 3 populations— English, Dutch, and Canadian—plus an association close to significance in an Irish collection.