Isolation and mutagenesis of a capsule-like complex (CLC) from Francisella tularensis, and contribution of the CLC to F. tularensis virulence in mice.

While similar numbers of the mutant from low dose challenge were present in the lungs at day 2 PI, recovery dropped off to significantly fewer numbers by day 4 PI ( P <0.05), and to a highly significant difference by day 7 PI ( P <0.005) ( Fig. 10A ).

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