Angiogenesis in urinary bladder carcinoma as defined by microvessel density (MVD) after immunohistochemical staining for Factor VIII and CD31.

Interestingly, the expression of both markers increased with tumor stage and grade, with significant correlation to tumor stage: p =0.001 and p =.002, respectively, and a highly significant correlation with tumor grade ( p =0.0001 for both) ( Table 2 ).

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