ALMS1-deficient fibroblasts over-express extra-cellular matrix components, display cell cycle delay and are resistant to apoptosis.

As shown in Figure 3a , the expression levels of all analyzed genes ( POSTN , ACTA2 , collagens) were higher in ALMS than in control fibroblasts (from 1.5 to 151 fold increase) with a highly significant correlation between microarray data and qPCR determinations ( Figure 3b ) (Pearson coefficient = 0.8) (see also Figure S6 ).

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