Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance.

Furthermore, the drug × smoking status interactions failed to reach significance [ F (1,37) = 0.001, P = 0.98, F (1,37) = 0.18, P = 0.67, respectively). fMRI data—overall nicotine effects The BOLD analysis ( N = 39) revealed activation in response to infrequent target stimuli in the post-central gyrus, pre-central gyrus, cerebellum, supramarginal gyrus, insula, frontal operculum, inferior frontal gyrus, middle frontal gyrus, anterior cingulate cortex, and lateral occipital cortex (Fig. 1 .; see Table 2 for MNI coordinates and Z values).

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