The stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6 in S. cerevisiae.

To further explore this relationship, we preformed a linear regression for Tup1 binding by the number of recruiter proteins bound and discovered a highly significant regression of R 2 = 0.500 (P<1×10 −10 ) ( Figure 2D ) .

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