The 5-day growth delay observed for this very aggressive tumor was exciting and highly significant in light of the dismal prognosis of patients with brain tumors, being equivalent to a bout 4-month extension in life for a patient with a 1-year life expectancy [26] , [27] .
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Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model.
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