A customized pigmentation SNP array identifies a novel SNP associated with melanoma predisposition in the SLC45A2 gene.

PLoS One · 2011 · PMC3084811 · PMID 21559390

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0.0880

closest p · 1.8× alpha

0.0880

boldest claim

The sentences

marginally significantp = 0.088so close (0.05 < p ≤ 0.1)

On the other hand, an increased risk, although marginally significant, appeared with the combination of rare alleles at TYR and ADAMTS20 (OR = 1.54; p = 0.088) (See Table 2 ).

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a trend toward significancep- value = 0.088so close (0.05 < p ≤ 0.1)

We observed a risk effect when two or three rare alleles were present at both loci , rs17793678 C/T and rs1510521 G/-, OR = 1.41 (95% CI 1.12–1.78) p- value = 0.004, and when three or four rare alleles, rs17793678 T/T and rs1510521 G/- were present, we obtained an OR = 1.54 (95% CI 0.96–2.48) with a trend toward significance (p- value = 0.088).

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