Moreover, a recent report about primary NSCLC mouse xenograft models treated with SAG unveiled a highly significant upregulation of genes involved in pathways like SAC and chromosome segregation in the primary NSCLC xenograft models which are SAG responders compared to non-responder [7] , indicating that the phenotype observed in vitro after treatment with the high concentration of SAG is mainly responsible for tumor cells killing.
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Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.
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