The benzene metabolite para-benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral blood mononuclear cells at low concentrations.

Under these conditions, a significant increase of micronuclei occurred between 0.04 and 0.2 μg p -BQ: In 4 out of 11 experiments using 20–28 ng/ml PMA, significance was reached in terms of a positive trend test (experiments 7, 9, 12 and 14).

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