Considering scores between unrelated proteins in the search database improves profile comparison.

BMC Bioinformatics · 2009 · PMC3087343 · PMID 19961610

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closest p

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highly significantno p-value reported

Depending on these properties, the same score value can be highly significant for one pair of profiles and marginal for another.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.