Microscopic analysis of protein oxidative damage: effect of carbonylation on structure, dynamics, and aggregability of villin headpiece.

Carbonylation increases aggregability of negatively charged proteins as well, but to a somewhat lower extent (ln(ν mut /ν wt ) = 2.39 ± 0.73 for Lys to Asa, and ln(ν mut /ν wt ) = 2.87 ± 0.73 for Arg to Gsa), which is still extremely significant.

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