Then, on the basis of the PCA, others were picked that had changed significantly in response to either siRNA, starting with those that had narrowly escaped significance with the second siRNA. 17 down-regulated spots were also picked, from those that had decreased significantly in response to both siRNAs (Additional file 1 ).
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Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.
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