An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.

Comparing miR-200c∼141 cluster expression with TGF-β1, TGF-β2, ZEB1, and ZEB2, we found highly significant inverse correlations (p < 0.01) for each pairwise comparison, the only exception being that miR-141 and TGF-β1 levels were not significantly correlated ( Figure 7 and Supplemental Table 1).

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