Barely Significant
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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

Nat Neurosci · 2011 · PMC3094729 · PMID 21358643

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hedged sentence
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The sentences

highly significantp <0.001actually significant
A highly significant fraction (74%) of all downregulated genes were direct targets of TDP-43 in comparison to genes that were unchanged (52%, p <0.001) or upregulated (18%, p <1×10 −17 ) upon TDP-43 depletion.

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