Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions.

This viewpoint is important because different phospho-forms may have different biological effects—both the numbers and the positions of phosphorylations may be significant—as observed for signalling proteins ( Cha and Shapiro, 2001 ), transcription factors ( Pufall et al, 2005 ), transcriptional co-activators ( Wu et al, 2004 ), ion channels ( Park et al, 2006 ) and circadian clock components ( Baker et al, 2009 ).

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