Extraction of consensus protein patterns in regions containing non-proline cis peptide bonds and their functional assessment.

Moreover, cis -nonPro peptide bonds are actually found to occur more frequently than previously thought and are often located at or near functionally important regions of the proteins, such as active sites [ 2 ] and dimerization interfaces [ 3 ]; these facts triggered further studies in order to unravel the molecular mechanism of these rare but highly significant configurations of the peptide bonds (Figure 1 ).

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