Bioactive electrospun scaffolds delivering growth factors and genes for tissue engineering applications.

The governing principle of this approach is using scaffolds to deliver appropriate biomolecules to the defect area; the biomolecules are released from the scaffolds in a controlled manner and may recruit progenitor cells toward the defect area and promote their proliferation and differentiation, thereby enhancing tissue regeneration. In recent years, an increasing trend toward the combination of these two approaches is observed ( 5 – 8 ), because the scaffolds with controlled release of biomolecules can induce the seeded cells to proliferate and differentiate during an ex vivo pre-culture period, thereby encouraging tissue formation after implantation in vivo .

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