The top 23 returns of an HHPRED fold search by the human IGFLR1 cytoplasmic domain are uniformly DD family members (with a top score of 97 and attached probability value of 99.3, E-value of 1.6 × 10 −13 , and p value of 7.1 × 10 −18 ), indicating a highly significant match.
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Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
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