HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction.

mBio · 2011 · PMC3101777 · PMID 21610122

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highly significantno p-value reported

Importantly and consistently, β-TrCP-depleted TZM-bl cells displayed a highly significant, albeit slightly diminished, capacity to support Vpu’s inhibitory influence on CD317 recycling ( Fig. 5G ).

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