Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients.

Br J Cancer · 2011 · PMC3101927 · PMID 21468050

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1400

boldest claim

The sentences

marginal significanceP =0.06so close (0.05 < p ≤ 0.1)

Regarding DFS ( Figure 4C ), medium vs low HE4 tertiles was significantly correlated with decreased DFS ( P =0.04), whereas the difference between high and low HE4 tertiles showed a marginal significance ( P =0.06).

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marginally significantP =0.08so close (0.05 < p ≤ 0.1)

Non-endometrioid EC histological subtype, along with advanced FIGO stage, were identified as independent predictive factors for poor OS ( P =0.01 and P =0.04, respectively, Table 4A ), whereas sHE4 levels (medium vs low tertile) were shown to be marginally significant as prognostic factor for shorter OS ( P =0.08, Table 4A ).

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trend toward significanceP =0.14not close (p > 0.1)

Regarding DFS, neither clinical parameters nor sHE4 levels were indicative of disease recurrence, even if elevated sHE4 levels exhibited the highest trend toward significance ( P =0.14 and P =0.17, Table 4A ).

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