Histological analysis 6 weeks after induction of AMI Cardiac tissue specimens obtained 6 weeks after ligation of the LAD and stained according to the Elastica van Gieson protocol showed that hearts from rats injected with apoptotic PBMC suspensions showed a highly significant reduction of infarction area.
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Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction.
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