Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.

Consistent with these morphological changes, gene expression profiling by the microarray of wt and Mia3 −/− forelimb RNA collected from 12.5-, 13.5-, and 14.5-dpc embryos ( n = 5 per genotype) reveals a highly significant increase in genes associated with the UPR ( Fig. 8 A ).

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