Relationship between esomeprazole dose and timing to heartburn resolution in selected patients with gastroesophageal reflux disease.

However, a nonsignificant trend was seen toward improved nocturnal heartburn resolution with esomeprazole 40 mg twice daily compared with esomeprazole 20 mg once daily and 40 mg once daily in terms of heartburn-free nights during week 4 ( Table 2 ).

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