Genetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development.

Furthermore, on the basis of a very stringent multiplicative model, the borderline significance P values for the interaction between rs12539530 and rs827421 ( P = 0.07) and between rs12539530 and rs7739506 ( P = 0.09) are in line with the suggestion that an interaction between rs12539530 and ESR1 polymorphism is linked to breast cancer risk.

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The possibility of false-positives due to multiple testing is less likely, because the permutation test showed on the basis of 10,000 random permutations that these two associations were borderline significant or significant ( P = 0.08 and P = 0.03, respectively) (Table S1 in Additional file 1 ).

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