Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.

Partial least squares regression of lipidomic data related to FCS showed that the changes in the top-ranking lipids associate with the increase of adipocyte cell size in obesity ( Figure S3 ). In line with this, triacylglycerols were also elevated in the adipose tissue of obese twins at the marginal significance level false discovery rate (FDR) q <0.1 ( Figure S4 ).

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When comparing obesity-discordant twin pairs (heavy versus lean twin) using pairwise t test, none of the shown triglycerides reached FDR q< 0.05, but they were all marginally significant at FDR q< 0.1.

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