However, citalopram and reboxetine induced a strong and highly significant increase in the phosphorylation of the immaturely glycosylated form of TrkB in p CPA and DSP4 treated mice, respectively ( Figure 5B ).
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Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade.
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