A large scale survey reveals that chromosomal copy-number alterations significantly affect gene modules involved in cancer initiation and progression.

For instance, the highly significant "neurological process" (p = 4.45 × 10 -12 ) and their descendants (see Figure 2 ) are probably related to the undifferentiation process o neuronal cells.

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The biological process "telomere maintenance" (with p = 0.14336, a marginal significance if we consider a liberal threshold of 0.15) is quite general but clearly accounts for the immortalization of the cancer cells.

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