The implications of relationships between human diseases and metabolic subpathways.

We found that the degree distribution of the subpathway nodes of the actual DMSPN was significantly broader than that of the random networks (P-value<10e–10, see SI Figure S2A ), whereas the distribution of disease nodes did not display such a highly significant difference (P-value = 0.02, see SI Figure S2B ), suggesting that the different subpathways in the DMSPN possessed the considerable differences with respect to causing diseases.

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