borderline significantp = 0.05
The results of change in biochemical markers are summarized in Table 2 . In the responder analysis, the relative risk for a positive response was borderline significant ( p = 0.05) for active LEDT over placebo RR = 1.67 [95% CI 1.00–1.67], but there were no significant differences for any of the other treatment comparisons (Table 3 ).