The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner.

On Guam, where ALS-PDC has been studied scientifically for over 60 years [4] , the disease has been repeatedly linked to ingestion of food derived from cycad seed, with highly significant correlations for the cycasin content of cycad flour and for ALS and PD forms of the disease in both males and females [1] , [5] , [12] , [13] .

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