Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

Although Tier 1 envelope glycoproteins were highly cold-sensitive relative to the Tier 2 panel, there was only a weak trend between cold sensitivity and the level of global reactivity to inhibitor binding, as measured by the neutralization-to-binding index for the 4 inhibitors ( Figure S13A ).

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When a comparison between Tier 1 and Tier 2 viral envelope glycoproteins was made for the neutralization-to-binding ratios of the individual inhibitors rather than the averaged index, a statistically significant difference was found for sCD4 and a trend towards significance for the 4E10 antibody ( Figure S12, A–D ).

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