There was a highly significant inverse relationship between body temperature and DA neurotoxicity in all METH-treated animals (i.e. animals treated with METH alone, METH plus AMPT, and METH plus AMPT plus l -DOPA), with animals achieving the highest core temperatures having the lowest DA levels 1 week after METH treatment, regardless of the drugs used in combination with METH ( Fig. 4 ).
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Dopamine is not essential for the development of methamphetamine-induced neurotoxicity.
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