Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.

PLoS Biol · 2011 · PMC3125158 · PMID 21738444

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highly significantno p-value reported

We then added to the reaction mix increasing concentrations of HMGB1, and we noted a highly significant dose-dependent increase in the mononucleosome band (lanes 6–9), reaching a maximal yield at 1 μg/ml.

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