Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma.

normal (N) based on the Mann-Whitney test were: significant for palladin (p-value = 0.016; median = 0.75 in T and 0.375 in N), marginally significant for α-SMA (p-value = 0.078; median = 0.75 in T and 0.5 in N), significant for EDA (p-value = 0.010; median = 0.625 in T and 0.125 in N) and relatively unchanged for stroma control pan-collagen (p-value = 0.364; median = 0.50 in T and 0.50 in N).

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Strikingly, the predictive value of this stromal marker was highly significant in patients who had not developed metastasis suggesting that it could constitute a high risk marker in this patient population.

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