Furthermore, a short-term Mg dietary deficiency (21 days) in rat results in an upregulation of the two major subunits of serine palmitoyl-CoA-transferase, serine palmitoyl transferase (SPT 1) and SPT 2 (the rate-limiting enzymes responsible for the de novo biosynthesis of ceramides), concomitant with a highly significant release of mitochondrial cytochrome c in left ventricular, right ventricular, atrial, and abdominal aortic smooth muscle [ 138 ].
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