Individual trabeculae segmentation (ITS)-based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis.

This μFE analysis technique has been thoroughly validated on HR-pQCT images with the registered μCT images as a gold standard.( 44 ) Correlations between HR-pQCT- and μCT-based elastic moduli of trabecular subvolumes were highly significant, with r 2 > 0.90.( 44 ) The accuracy of ITS measurements was also investigated in a preliminary validation study.( 45 ) Most ITS measurements of HR-pQCT images correlated significantly with those of the registered μCT images, and plate-related parameters yielded better correlations than rod-related parameters.

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