Protein structural modularity and robustness are associated with evolvability.

Further evidence for the positive association between contact density and the evolvability index is that these two indices have a borderline significant rank correlation ( P = 0.0682 for Spearman’s rank correlation test, one-tailed), though they do not have a significant linear correlation ( P = 0.391 for Pearson's correlation test, one-tailed).

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We find that there is a highly significant correlation between the number of residues and the number of helices and strands ( fig. 2 ) and thus, that our normalization procedure is appropriate.

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