highly significantp = 2.05 ×10 −9
Cyclization properties, especially alicyclic, have a moderate but highly significant Pearson correlation (ρ = 0.33, p = 2.05 ×10 −9 between alicyclic and polycyclic, ρ = 0.36, p = 6.72 ×10 −11 between alicyclic and heterocyclic, and ρ = 0.21, p = 1.95 ×10 −4 between aromatic and heterocyclic).