a nonsignificant trendP = 0.13
While this represented a nonsignificant trend toward lower risk of major events associated with CVD by 9% (relative risk [RR]: 0.91, 95% confidence interval [CI]: 0.80–1.03; P = 0.13) with aspirin in the overall group, analysis by age indicated that aspirin significantly reduced major events in women aged ≥ 65 years (RR: 0.74, 95% CI: 0.59–0.92] in women aged ≥ 65 years vs (RR: 1.01, 95% CI: 0.81–1.26 in women aged 45–54 years).