Indeed, we found highly significant increases in IL-17 and TNF-α in cocultures containing type 1 diabetic CD4+CD25+ cells compared with control CD4+CD25+ cells ( Fig. 3 A ; for paired analysis, see Fig. 3 B ).
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Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes.
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